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Analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Xiaodong Bai

PROVIDER: E-GEOD-55393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice.

Sundermeier Thomas R TR Zhang Ning N Vinberg Frans F Mustafi Debarshi D Kohno Hideo H Golczak Marcin M Bai Xiaodong X Maeda Akiko A Kefalov Vladimir J VJ Palczewski Krzysztof K

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140508 8

Photoreceptor cell death is the proximal cause of blindness in many retinal degenerative disorders; hence, understanding the gene regulatory networks that promote photoreceptor survival is at the forefront of efforts to combat blindness. Down-regulation of the microRNA (miRNA)-processing enzyme DICER1 in the retinal pigmented epithelium has been implicated in geographic atrophy, an advanced form of age-related macular degeneration (AMD). However, little is known about the function of DICER1 in m ...[more]

PMID: 24812086

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