Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wencai Ma
PROVIDER: E-GEOD-55533 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jacamo Rodrigo R Chen Ye Y Wang Zhiqiang Z Ma Wencai W Zhang Min M Spaeth Erika L EL Wang Ying Y Battula Venkata L VL Mak Po Yee PY Schallmoser Katharina K Ruvolo Peter P Schober Wendy D WD Shpall Elizabeth J EJ Nguyen Martin H MH Strunk Dirk D Bueso-Ramos Carlos E CE Konoplev Sergej S Davis R Eric RE Konopleva Marina M Andreeff Michael M
Blood 20140305 17
Leukemia cells are protected from chemotherapy-induced apoptosis by their interactions with bone marrow mesenchymal stromal cells (BM-MSCs). Yet the underlying mechanisms associated with this protective effect remain unclear. Genome-wide gene expression profiling of BM-MSCs revealed that coculture with leukemia cells upregulated the transcription of genes associated with nuclear factor (NF)-κB signaling. Moreover, primary BM-MSCs from leukemia patients expressed NF-κB target genes at higher leve ...[more]