Toxicogenomic profiling in the whole zebrafish embryo after exposure to reference hepatotoxicants.
Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Jeroen Pennings
PROVIDER: E-GEOD-55618 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.
Driessen Marja M Vitins Alexa P AP Pennings Jeroen L A JL Kienhuis Anne S AS Water Bob van de Bv van der Ven Leo T M LT
Toxicology letters 20141124 2
The zebrafish embryo (ZFE) is a promising alternative, non-rodent model in toxicology, which has an advantage over the traditionally used models as it contains complete biological complexity and provides a medium to high-throughput setting. Here, we assess how the ZFE compares to the traditionally used models for liver toxicity testing, i.e., in vivo mouse and rat liver, in vitro mouse and rat hepatocytes, and primary human hepatocytes. For this comparison, we analyzed gene expression changes in ...[more]
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