H3K4 tri-methylation provides an epigenetic signature of active enhancers

ABSTRACT: Combinations of post-translational histone modifications shape the chromatin landscape during cell development in eukaryotes. However, little is known about the modifications exactly delineating functionally engaged regulatory elements. For example, although histone H3 lysine 4 mono-methylation (H3K4me1) indicates the presence of transcriptional gene enhancers, it does not provide clear-cut information about their actual position and stage-specific activity. Histone marks were, therefore, studied here at genomic loci differentially expressed in early stages of T-lymphocyte development. The concomitant presence of the three H3K4 methylation states (H3K4me1/2/3) was found to clearly reflect the activity of bona fide T-cell gene enhancers. Globally, gain or loss of H3K4me2/3 at distal genomic

ORGANISM(S): Mus musculus

SUBMITTER: Aurelie Bergon 

PROVIDER: E-GEOD-55635 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress