Re-replication generates whole-chromosomal instability and anueploidy

ABSTRACT: Aneuploidy, a hallmark of cancer, often arises from whole chromosome instability (W-CIN). Many cancers exhibiting W-CIN, however, show no direct insult to the mitotic proteins that ensure proper segregation of chromosomes. This has stimulated interest in identifying defects in non-mitotic processes that might disrupt chromosome behavior in mitosis. Here we show in Saccharomyces cerevisiae that re-replication of centromeric DNA, caused by deregulation of replication initiation proteins, efficiently induces chromosome instability––either by causing missegregation of both sister chromatids to one daughter cell or by triggering formation of an extra chromatid through a pathway dependent on homologous recombination. Given the emerging connections between the deregulation of replication init

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Stacey Hanlon 

PROVIDER: E-GEOD-55641 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress