Variant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hamish King
PROVIDER: E-GEOD-55698 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.
Blackledge Neil P NP Farcas Anca M AM Kondo Takashi T King Hamish W HW McGouran Joanna F JF Hanssen Lars L P LLP Hanssen Lars L P LLP Ito Shinsuke S Cooper Sarah S Kondo Kaori K Koseki Yoko Y Ishikura Tomoyuki T Long Hannah K HK Sheahan Thomas W TW Brockdorff Neil N Kessler Benedikt M BM Koseki Haruhiko H Klose Robert J RJ
Cell 20140522 6
Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain poorly understood. Recruitment of PRC1 to target sites has been proposed to occur through a hierarchical process, dependent on prior nucleation of PRC2 and placement of H3K27me3. Here ...[more]
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