Effect of CSF1R inhibition in tumor macrophages on gene expression in metastatic epithelial cells

ABSTRACT: Metastasis is the primary cause of mortality in breast cancer patients. Tumor associated macrophages (TAMs) are active collaborators in mediating several steps of the tumor metastatic cascade, but the molecular details governing this collaboration remain ill-defined. Colony Stimulating Factor 1 (CSF1), a factor critical for macrophage differentiation and survival, functions to recruit TAMs to the primary tumor site, and anti-CSF1 therapies are in clinical trials.In this study, we tested the effect of inhibiting CSF1 signaling in macrophages on gene expression in metastatic tumor cells in mouse models of breast cancer metastasis. Tumor cells were sorted from lung metastases from control and CSF1R inhibitor treated mice. Several pro-tumor processes were significantly affected by CSF1R inhib

ORGANISM(S): Mus musculus

SUBMITTER: Haritha Mathsyaraja 

PROVIDER: E-GEOD-55855 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress