Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wolfgang Wagner
PROVIDER: E-GEOD-55888 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schellenberg Anne A Joussen Sylvia S Moser Kristin K Hampe Nico N Hersch Nils N Hemeda Hatim H Schnitker Jan J Denecke Bernd B Lin Qiong Q Pallua Norbert N Zenke Martin M Merkel Rudolf R Hoffmann Bernd B Wagner Wolfgang W
Biomaterials 20140510 24
Matrix elasticity guides differentiation of mesenchymal stem cells (MSCs) but it is unclear if these effects are only transient - while the cells reside on the substrate - or if they reflect persistent lineage commitment. In this study, MSCs were continuously culture-expanded in parallel either on tissue culture plastic (TCP) or on polydimethylsiloxane (PDMS) gels of different elasticity to compare impact on replicative senescence, in vitro differentiation, gene expression, and DNA methylation ( ...[more]