Unknown,Transcriptomics,Genomics,Proteomics

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Long noncoding RNA as putative biomarkers for protstate cancer detection [Set 1]


ABSTRACT: To identify which lncRNAs are differentially expressed in prostate cancer, total RNA from prostate cancer cell line, PC3, and normal epithelial prostatic cells were screened using NCode (Life Technologies) . The NCode microarray is designed to interrogate 12,784 lncRNAs and 25,409 mRNA target protein-coding genes. Gene expression in prostate epithelial cells and PC3 was measured. Three independent experiments (biological replicates) were performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Jian-Liang Li 

PROVIDER: E-GEOD-55908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in pr  ...[more]

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