Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: M. Simo Arredouani
PROVIDER: E-GEOD-55945 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Arredouani Mohamed S MS Lu Bin B Bhasin Manoj M Eljanne Miriam M Yue Wen W Mosquera Juan-Miguel JM Bubley Glenn J GJ Li Vivian V Rubin Mark A MA Libermann Towia A TA Sanda Martin G MG
Clinical cancer research : an official journal of the American Association for Cancer Research 20090908 18
<h4>Purpose</h4>Identification of novel biomarkers and immunotherapy targets for prostate cancer (PCa) is crucial to better diagnosis and therapy. We sought to identify novel PCa tumor-associated antigens (TAA) that are expressed in PCa, absent in nonprostate human tissue, and immunogenic for immune responses restricted by human HLA.<h4>Experimental design and results</h4>Using microarray analysis of normal and cancerous human prostate tissues, we identified 1,063 genes overexpressed in PCa. Aft ...[more]