Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yongmei Liu
PROVIDER: E-GEOD-56047 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Reynolds Lindsay M LM Taylor Jackson R JR Ding Jingzhong J Lohman Kurt K Johnson Craig C Siscovick David D Burke Gregory G Post Wendy W Shea Steven S Jacobs David R DR Stunnenberg Hendrik H Kritchevsky Stephen B SB Hoeschele Ina I McCall Charles E CE Herrington David D Tracy Russell P RP Liu Yongmei Y
Nature communications 20141118
Age-related variations in DNA methylation have been reported; however, the functional relevance of these differentially methylated sites (age-dMS) are unclear. Here we report potentially functional age-dMS, defined as age- and cis-gene expression-associated methylation sites (age-eMS), identified by integrating genome-wide CpG methylation and gene expression profiles collected ex vivo from circulating T cells (227 CD4+ samples) and monocytes (1,264 CD14+ samples, age range: 55-94 years). None of ...[more]