Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Adult Drosophila with controled microbiota


ABSTRACT: The microbial population that live within the gut of animals influences their physiology. We used axenic and recolonized flies to identify genes whose expression is modulated by the presence of a bacterial flora in the gut. We identified several up regulated genes, most of which are described as enriched in the midgut, and related either to immunity or to metabolism. This work also suggests that most microbiota regulated genes are Relish dependent. We raised axenic Flies and either : (1) kept them germ free or (2) recolonized their environment with a set of 4 known commensal bacteria of lab-raised drosophila (Commensalibacter intestini, Lactobacillus plantarum, Lactobacillus brevis, Acetobacter pomorum). Flies were maintained in their respective (axenic or recolonized) environment from emergence to 7 days of age. Then females were collected, and total RNA extraction was performed on groups of 20 whole bodies.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: François Leulier 

PROVIDER: E-GEOD-56173 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling.

Erkosar Berra B   Defaye Arnaud A   Bozonnet Noémie N   Puthier Denis D   Royet Julien J   Leulier François F  

PloS one 20140414 4


Most metazoans engage in mutualistic interactions with their intestinal microbiota. Despite recent progress the molecular mechanisms through which microbiota exerts its beneficial influences on host physiology are still largely uncharacterized. Here we use axenic Drosophila melanogaster adults associated with a standardized microbiota composed of a defined set of commensal bacterial strains to study the impact of microbiota association on its host transcriptome. Our results demonstrate that Dros  ...[more]

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