Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Vera Martins
PROVIDER: E-GEOD-56419 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Martins Vera C VC Busch Katrin K Juraeva Dilafruz D Blum Carmen C Ludwig Carolin C Rasche Volker V Lasitschka Felix F Mastitsky Sergey E SE Brors Benedikt B Hielscher Thomas T Fehling Hans Joerg HJ Rodewald Hans-Reimer HR
Nature 20140514 7501
Cell competition is an emerging principle underlying selection for cellular fitness during development and disease. Competition may be relevant for cancer, but an experimental link between defects in competition and tumorigenesis is elusive. In the thymus, T lymphocytes develop from precursors that are constantly replaced by bone-marrow-derived progenitors. Here we show that in mice this turnover is regulated by natural cell competition between 'young' bone-marrow-derived and 'old' thymus-reside ...[more]