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Cell competition is a tumor suppressor mechanism in the thymus.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Vera Martins

PROVIDER: E-GEOD-56419 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cell competition is a tumour suppressor mechanism in the thymus.

Martins Vera C VC Busch Katrin K Juraeva Dilafruz D Blum Carmen C Ludwig Carolin C Rasche Volker V Lasitschka Felix F Mastitsky Sergey E SE Brors Benedikt B Hielscher Thomas T Fehling Hans Joerg HJ Rodewald Hans-Reimer HR

Nature 20140514 7501

Cell competition is an emerging principle underlying selection for cellular fitness during development and disease. Competition may be relevant for cancer, but an experimental link between defects in competition and tumorigenesis is elusive. In the thymus, T lymphocytes develop from precursors that are constantly replaced by bone-marrow-derived progenitors. Here we show that in mice this turnover is regulated by natural cell competition between 'young' bone-marrow-derived and 'old' thymus-reside ...[more]

PMID: 24828041

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