Unknown,Transcriptomics,Genomics,Proteomics

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High throughput sequencing of B.henselae infected and non-infected I. ricinus salivary glands


ABSTRACT: In order to select genes that are differentially expressed in salivary glands during Ixodes ricinus infection by Bartonella henselae we compare the transcriptome of infected and non-infected salivary glands I. ricinus from a pathogen free colony were infected -or not- with B. henselae at the larval and then the nymphal stage and salivary glands of the resulting females adult were dissected for RNA extraction. 454 sequencing was performed on pooled conditions in order to obtain a reference databank. Infected and non-infected samples were then sequenced separatly with illumina, blaston teh reference datbank and compared.

ORGANISM(S): Ixodes ricinus

SUBMITTER: Sarah Bonnet 

PROVIDER: E-GEOD-56746 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

IrSPI, a tick serine protease inhibitor involved in tick feeding and Bartonella henselae infection.

Liu Xiang Ye XY   de la Fuente Jose J   Cote Martine M   Galindo Ruth C RC   Moutailler Sara S   Vayssier-Taussat Muriel M   Bonnet Sarah I SI  

PLoS neglected tropical diseases 20140724 7


Ixodes ricinus is the most widespread and abundant tick in Europe, frequently bites humans, and is the vector of several pathogens including those responsible for Lyme disease, Tick-Borne Encephalitis, anaplasmosis, babesiosis and bartonellosis. These tick-borne pathogens are transmitted to vertebrate hosts via tick saliva during blood feeding, and tick salivary gland (SG) factors are likely implicated in transmission. In order to identify such tick factors, we characterized the transcriptome of  ...[more]

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