Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Olivier Elemento
PROVIDER: E-GEOD-56762 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wen Duancheng D Banaszynski Laura A LA Liu Ying Y Geng Fuqiang F Noh Kyung-Min KM Xiang Jenny J Elemento Olivier O Rosenwaks Zev Z Allis C David CD Rafii Shahin S
Proceedings of the National Academy of Sciences of the United States of America 20140505 20
Mature oocyte cytoplasm can reprogram somatic cell nuclei to the pluripotent state through a series of sequential events including protein exchange between the donor nucleus and ooplasm, chromatin remodeling, and pluripotency gene reactivation. Maternal factors that are responsible for this reprogramming process remain largely unidentified. Here, we demonstrate that knockdown of histone variant H3.3 in mouse oocytes results in compromised reprogramming and down-regulation of key pluripotency gen ...[more]