Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genome wide TFIIB binding during postnatal and pressure-induced cardiac hypertrophy

ABSTRACT: Purpose: To identify the differential TFIIB bindingl patterns during postnatal cardiac growth, pressure-induced cardiac hypertrophy and adult mouse hearts Methods: Hearts were extracted from 1-2day old C57 mice, from mice subjecetd to Transaortic coarctation or adult mice. The hearts were sent to Active Motif for TFIIB- ChIP-Seq. Results: In accordance with previosly published data (Sayed D, et. al. JBC, 2013 Jan 25;288(4):2546-58) with genome wide polII and H3K9ac status during cardiac hypertrophy (GSE50637), Denovo TFIIB recruitment was restricted to speclaized genes with cardiac hypertrophy. Hearts were extracted from 1-2day old C57 mice, from mice subjecetd to Transaortic coarctation or adult mice. The hearts were sent to Active Motif for TFIIB- ChIP-Seq.

ORGANISM(S): Mus musculus

SUBMITTER: Maha Abdellatif

PROVIDER: E-GEOD-56813 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription.

Sayed Danish D Yang Zhi Z He Minzhen M Pfleger Jessica M JM Abdellatif Maha M

Circulation. Heart failure 20141114 1

<h4>Background</h4>We previously reported that specialized and housekeeping genes are differentially regulated via de novo recruitment and pause-release of RNA polymerase II, respectively, during cardiac hypertrophy. However, the significance of this finding remains to be examined. Therefore, the purpose of this study was to determine the mechanisms that differentially regulate these gene groups and exploit them for therapeutic targeting.<h4>Methods and results</h4>Here, we show that general tra ...[more]

PMID: 25398966

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Dataset Information

Genome wide TFIIB binding during postnatal and pressure-induced cardiac hypertrophy

Publications

Acute targeting of general transcription factor IIB restricts cardiac hypertrophy via selective inhibition of gene transcription.

Similar Datasets

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