Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Raja Jothi
PROVIDER: E-GEOD-56839 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Oldfield Andrew J AJ Yang Pengyi P Conway Amanda E AE Cinghu Senthilkumar S Freudenberg Johannes M JM Yellaboina Sailu S Jothi Raja R
Molecular cell 20140814 5
Cell type-specific master transcription factors (TFs) play vital roles in defining cell identity and function. However, the roles ubiquitous factors play in the specification of cell identity remain underappreciated. Here we show that the ubiquitous CCAAT-binding NF-Y complex is required for the maintenance of embryonic stem cell (ESC) identity and is an essential component of the core pluripotency network. Genome-wide studies in ESCs and neurons reveal that NF-Y regulates not only genes with ho ...[more]