PRPF6 regulated alternative splicing in colon cancer cell lines
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jinfeng Liu
PROVIDER: E-GEOD-56846 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
Adler Adam S AS McCleland Mark L ML Yee Sharon S Yaylaoglu Murat M Hussain Sofia S Cosino Ely E Quinones Gabriel G Modrusan Zora Z Seshagiri Somasekar S Torres Eric E Chopra Vivek S VS Haley Benjamin B Zhang Zemin Z Blackwood Elizabeth M EM Singh Mallika M Junttila Melissa M Stephan Jean-Philippe JP Liu Jinfeng J Pau Gregoire G Fearon Eric R ER Jiang Zhaoshi Z Firestein Ron R
Genes & development 20140501 10
The spliceosome machinery is composed of multimeric protein complexes that generate a diverse repertoire of mRNA through coordinated splicing of heteronuclear RNAs. While somatic mutations in spliceosome components have been discovered in several cancer types, the molecular bases and consequences of spliceosome aberrations in cancer are poorly understood. Here we report for the first time that PRPF6, a member of the tri-snRNP (small ribonucleoprotein) spliceosome complex, drives cancer prolifera ...[more]
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