Dicer knockout NSCLC RNAseq and miRseq
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sidi Chen
PROVIDER: E-GEOD-57043 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global microRNA depletion suppresses tumor angiogenesis.
Chen Sidi S Xue Yuan Y Wu Xuebing X Le Cong C Bhutkar Arjun A Bell Eric L EL Zhang Feng F Langer Robert R Sharp Phillip A PA
Genes & development 20140501 10
MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signaling. Expression profiling revealed that angiogenesis genes were significantly down-regulated as a result of the microRNA deficiency. Factor inhibiting hypoxia-inducible factor 1 (HIF-1), FIH1, is derepr ...[more]
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