Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Diana Low
PROVIDER: E-GEOD-57096 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hammoud Saher Sue SS Low Diana H P DH Yi Chongil C Carrell Douglas T DT Guccione Ernesto E Cairns Bradley R BR
Cell stem cell 20140515 2
Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs and during spermatogenesis. First, we define striking signaling and transcriptional differences between AGSC types, involving key self-renewal and proliferation pathways. Second, key ...[more]