Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Lung-resident myeloid-derived suppressor cells display dual functionality in experimental tuberculosis


ABSTRACT: Using cell-based approaches and experimental mouse models for pulmonary TB we unveiled MDSCs as new myeloid populations directly interacting with Mycobacterium tuberculosis (Mtb). MDSCs readily phagocytosed Mtb, released proinflammatory (IL-6, IL-1M-NM-1) and immunomodulatory (IL-10) cytokines while retaining their suppressive capacity. MDSCs were identified at the site of infection in disease-resistant and -susceptible mice during pulmonary TB. Excessive MDSC accumulation in lungs correlated with elevated surface expression of IL-4RM-NM-1 and heightened TB lethality. Microarray experiments were performed as dual-color hybridizations on Agilent mouse whole genome catalog 44K arrays. To compensate for dye-specific effects, a dye-reversal color-swap was applied.

ORGANISM(S): Mus musculus

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-57124 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.

Knaul Julia K JK   Jörg Sabine S   Oberbeck-Mueller Dagmar D   Heinemann Ellen E   Scheuermann Lisa L   Brinkmann Volker V   Mollenkopf Hans-Joachim HJ   Yeremeev Vladimir V   Kaufmann Stefan H E SH   Dorhoi Anca A  

American journal of respiratory and critical care medicine 20141101 9


<h4>Rationale</h4>Myeloid cells encompass distinct populations with unique functions during homeostasis and disease. Recently, a novel subset of innate cells, myeloid-derived suppressor cells (MDSCs), has been described in cancer, which suppresses T-cell responses and fosters disease progression. The role of MDSCs in infection is insufficiently addressed.<h4>Objectives</h4>To examine the presence and function of MDSCs during experimental pulmonary tuberculosis (TB) and further understand the imm  ...[more]

Similar Datasets

2014-12-21 | GSE57124 | GEO
2013-12-31 | E-GEOD-44848 | biostudies-arrayexpress
2014-01-01 | E-GEOD-45960 | biostudies-arrayexpress
2018-08-06 | PXD010659 | Pride
2019-11-22 | PXD000517 | Pride
2014-04-21 | E-GEOD-39163 | biostudies-arrayexpress
2016-07-01 | E-GEOD-66938 | biostudies-arrayexpress
2013-12-31 | GSE44848 | GEO
2014-10-21 | E-GEOD-62525 | biostudies-arrayexpress
2009-02-28 | E-GEOD-11199 | biostudies-arrayexpress