Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hans-Joachim Mollenkopf
PROVIDER: E-GEOD-57124 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Knaul Julia K JK Jörg Sabine S Oberbeck-Mueller Dagmar D Heinemann Ellen E Scheuermann Lisa L Brinkmann Volker V Mollenkopf Hans-Joachim HJ Yeremeev Vladimir V Kaufmann Stefan H E SH Dorhoi Anca A
American journal of respiratory and critical care medicine 20141101 9
<h4>Rationale</h4>Myeloid cells encompass distinct populations with unique functions during homeostasis and disease. Recently, a novel subset of innate cells, myeloid-derived suppressor cells (MDSCs), has been described in cancer, which suppresses T-cell responses and fosters disease progression. The role of MDSCs in infection is insufficiently addressed.<h4>Objectives</h4>To examine the presence and function of MDSCs during experimental pulmonary tuberculosis (TB) and further understand the imm ...[more]