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The Transcriptome of Utricle Hair Cell Regeneration in the Avian Inner Ear

ABSTRACT: A comprehensive transcriptome profile of chicken utricle hair cell across a 7 days regenerative time course. Compare gene expression changes in chicken utricle treated with streptomycin to the control. A total of 60 samples were collected from 11 different time points. Each time point contains at least 2 biological samples.

ORGANISM(S): Gallus gallus

SUBMITTER: Michael Lovett

PROVIDER: E-GEOD-57134 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcriptome of utricle hair cell regeneration in the avian inner ear.

Ku Yuan-Chieh YC Renaud Nicole A NA Veile Rose A RA Helms Cynthia C Voelker Courtney C J CC Warchol Mark E ME Lovett Michael M

The Journal of neuroscience : the official journal of the Society for Neuroscience 20140301 10

Sensory hair cell loss is the major cause of hearing and balance disorders. Mammals are incapable of sustained hair cell regeneration, but lower vertebrates can regenerate these mechano-electrical transducers. We present the first comprehensive transcriptome (by mRNA-Seq) of hair cell regeneration in the chick utricle. We provide pathway and pattern annotations and correlate these with the phenotypic events that occur during regeneration. These patterns are surprisingly synchronous and highly pu ...[more]

PMID: 24599453

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