Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yolande Ramos
PROVIDER: E-GEOD-57218 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ramos Yolande F M YF den Hollander Wouter W Bovée Judith V M G JV Bomer Nils N van der Breggen Ruud R Lakenberg Nico N Keurentjes J Christiaan JC Goeman Jelle J JJ Slagboom P Eline PE Nelissen Rob G H H RG Bos Steffan D SD Meulenbelt Ingrid I
PloS one 20140723 7
<h4>Objective</h4>Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process.<h4>Methods</h4>Genome wide gene expression was determined in paired samples of OA affected and preserved cartilage of the same joint using microarray analysis for 33 patients of the RAAK study. Results were replicated in independent samples by RT-qPCR and immunohistochemistry. Profiles were analyzed with the online analysis tools DAVI ...[more]