Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Francesco Neri
PROVIDER: E-GEOD-57250 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Neri Francesco F Incarnato Danny D Krepelova Anna A Dettori Daniela D Rapelli Stefania S Maldotti Mara M Parlato Caterina C Anselmi Francesca F Galvagni Federico F Oliviero Salvatore S
Nucleic acids research 20150429 14
Ten-eleven translocation (Tet) genes encode for a family of hydroxymethylase enzymes involved in regulating DNA methylation dynamics. Tet1 is highly expressed in mouse embryonic stem cells (ESCs) where it plays a critical role the pluripotency maintenance. Tet1 is also involved in cell reprogramming events and in cancer progression. Although the functional role of Tet1 has been largely studied, its regulation is poorly understood. Here we show that Tet1 gene is regulated, both in mouse and human ...[more]