Genomic analysis of low-grade serous ovarian carcinomas [ILOEF]
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ABSTRACT: Low-grade serous ovarian carcinomas are typically Ras-pathway mutated, TP53 wild-type, have limited chromosomal aberration, and are frequently associated with borderline tumors. By contrast, high-grade serous ovarian carcinoma lack Ras-pathway mutations, are invariably TP53 mutated, show widespread genomic change, and are commonly BRCA-pathway disrupted.We sought to identify differences in genomic copy number changes between co-existing borderline and invasive components of serous carcinoma. Paired co-existing borderline and invasive tumor components were sampled and profiled from formalin-fixed paraffin embedded tumors from 6 patients
ORGANISM(S): Homo sapiens
SUBMITTER: Dariush Etemadmoghadam
PROVIDER: E-GEOD-57276 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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