Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Linda Giudice
PROVIDER: E-GEOD-57356 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
Chen Joseph C JC Johnson Brittni A BA Erikson David W DW Piltonen Terhi T TT Barragan Fatima F Chu Simon S Kohgadai Nargis N Irwin Juan C JC Greene Warner C WC Giudice Linda C LC Roan Nadia R NR
Human reproduction (Oxford, England) 20140313 6
<h4>Study question</h4>How does seminal plasma (SP) affect the transcriptome of human primary endometrial epithelial cells (eEC) and stromal fibroblasts (eSF)?<h4>Summary answer</h4>Exposure of eEC and eSF to SP in vitro increases expression of genes and secreted proteins associated with cellular migration, proliferation, viability and inhibition of cell death.<h4>What is known already</h4>Studies in both humans and animals suggest that SP can access and induce physiological changes in the upper ...[more]
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