Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul Tesar
PROVIDER: E-GEOD-57407 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Factor Daniel C DC Corradin Olivia O Zentner Gabriel E GE Saiakhova Alina A Song Lingyun L Chenoweth Josh G JG McKay Ronald D RD Crawford Gregory E GE Scacheri Peter C PC Tesar Paul J PJ
Cell stem cell 20140601 6
Naive mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping we show that a small fraction of transcripts are differentially expressed between mESCs and mEpiSCs and that these genes show expected changes in chromatin at their promoters and enhancers. Unexpectedly, the cis-regulatory circuitry of genes that are expressed at identical levels between these cell state ...[more]