Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: NIEHS Microarray Core
PROVIDER: E-GEOD-57474 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Xiaoli X Li Bing B Li Wenguo W Ma Lijuan L Zheng Dongyan D Li Leping L Yang Weijing W Chu Min M Chen Wei W Mailman Richard B RB Zhu Jun J Fan Guoping G Archer Trevor K TK Wang Yuan Y
Stem cell reports 20140814 3
The SWI/SNF complex plays an important role in mouse embryonic stem cells (mESCs), but it remains to be determined whether this complex is required for the pluripotency of human ESCs (hESCs). Using RNAi, we demonstrated that depletion of BRG1, the catalytic subunit of the SWI/SNF complex, led to impaired self-renewing ability and dysregulated lineage specification of hESCs. A unique composition of the BRG1-SWI/SNF complex in hESCs was further defined by the presence of BRG1, BAF250A, BAF170, BAF ...[more]