Treatment of multiple myeloma cells with EZH2 small molecule inhibitor
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Relja Popovic
PROVIDER: E-GEOD-57478 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.
Popovic Relja R Martinez-Garcia Eva E Giannopoulou Eugenia G EG Zhang Quanwei Q Zhang Qingyang Q Ezponda Teresa T Shah Mrinal Y MY Zheng Yupeng Y Will Christine M CM Small Eliza C EC Hua Youjia Y Bulic Marinka M Jiang Yanwen Y Carrara Matteo M Calogero Raffaele A RA Kath William L WL Kelleher Neil L NL Wang Ji-Ping JP Elemento Olivier O Licht Jonathan D JD
PLoS genetics 20140904 9
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and its overexpression causes a global increase in H3K36me2, redistributing this mark in a broad, elevated level across the genome. Here, we demonstrate that an increased level of MMSET also induces a global reduction of lysine 27 trimethylation on histo ...[more]
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