Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Guenter Raddatz
PROVIDER: E-GEOD-57527 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20150325 10
Chronic inflammation represents a major risk factor for tumor formation, but the underlying mechanisms have remained largely unknown. Epigenetic mechanisms can record the effects of environmental challenges on the genome level and could therefore play an important role in the pathogenesis of inflammation-associated tumors. Using single-base methylation maps and transcriptome analyses of a colitis-induced mouse colon cancer model, we identified a novel epigenetic program that is characterized by ...[more]