Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Nir Hacohen
PROVIDER: E-GEOD-57542 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee Mark N MN Ye Chun C Villani Alexandra-Chloé AC Raj Towfique T Li Weibo W Eisenhaure Thomas M TM Imboywa Selina H SH Chipendo Portia I PI Ran F Ann FA Slowikowski Kamil K Ward Lucas D LD Raddassi Khadir K McCabe Cristin C Lee Michelle H MH Frohlich Irene Y IY Hafler David A DA Kellis Manolis M Raychaudhuri Soumya S Zhang Feng F Stranger Barbara E BE Benoist Christophe O CO De Jager Philip L PL Regev Aviv A Hacohen Nir N
Science (New York, N.Y.) 20140301 6175
Little is known about how human genetic variation affects the responses to environmental stimuli in the context of complex diseases. Experimental and computational approaches were applied to determine the effects of genetic variation on the induction of pathogen-responsive genes in human dendritic cells. We identified 121 common genetic variants associated in cis with variation in expression responses to Escherichia coli lipopolysaccharide, influenza, or interferon-β (IFN-β). We localized and va ...[more]