Gene expression in hippocampal sub-fields of 6.1 month old rTg4510 mice
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ABSTRACT: Microarrays were used to assess the gene expression patterns in the CA1, CA3, and dentate gyrus of the rTg4510 mouse line at 6.1 months of age. This line harbors a repressible mutant human Tau transgene under the Camk2a promoter. Both mice with just the tet-Transactivator alone and no transgenes ('double negative') were used as comparison groups. Cellular layers of the CA1, CA3, and dentate gyrus (DG) from 5 or 6 mice per genotype at age 6.1 months were laser capture dissected, RNA was isolated, and hybridization to Affymetrix microarrays performed.
ORGANISM(S): Mus musculus
SUBMITTER: John Corradi
PROVIDER: E-GEOD-57583 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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