Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

ABSTRACT: Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell antigen receptor (TCR)-driven signaling initially decreased the abundance of Id3, which led to the activation of a follicular regulatory T (TFR) cell–specific transcription signature. However, sustained lower abundance of Id2 and Id3 interfered with proper development of TFR cells. Depletion of Id2 and Id3 expression in Treg cells resulted in compromised maintenance and localization of the Treg cell population. Thus, Id2 and Id3 enforce TFR cell checkpoints and control the maintenance and homing of Treg cells. Treg mRNA profiles in lymph node from 3-week-old Id2fl/flId3fl/fl;Foxp3Cre/Cre (Id2 Id3 double-knockout) and control mice are generated by deep sequencing.

ORGANISM(S): Mus musculus

SUBMITTER: Kazuko Miyazaki 

PROVIDER: E-GEOD-57682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease.

Miyazaki Masaki M   Miyazaki Kazuko K   Chen Shuwen S   Itoi Manami M   Miller Marina M   Lu Li-Fan LF   Varki Nissi N   Chang Aaron N AN   Broide David H DH   Murre Cornelis C  

Nature immunology 20140629 8

Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell antigen receptor (TCR)-driven signaling initially decreased the abundance of Id3, which led to the activation of a follicular regulatory T (TFR) cell-specific transcription signature  ...[more]

Similar Datasets

Transcriptomics Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease
2014-06-29 | GSE57682 | GEO
Transcriptomics A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
2015-03-04 | E-GEOD-64779 | biostudies-arrayexpress
Transcriptomics scRNA-seq of human Tfh, Tfr and Treg cells sorted from Tonsil, Iliac Lymph Node and PBMCs
2021-04-22 | E-MTAB-10364 | biostudies-arrayexpress
Transcriptomics Regulatory T cells from colonic lamina propria [RNA-Seq]
2015-07-25 | E-GEOD-71304 | biostudies-arrayexpress
Transcriptomics Expression data from sorted Id3-GFP hi Id2-YFP int and Id3-GFP lo Id2-YFP hi activated CD8 T cells
2011-10-06 | E-GEOD-32675 | biostudies-arrayexpress
Genomics Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [ChIP-Seq]
2012-09-28 | E-GEOD-40684 | biostudies-arrayexpress
Transcriptomics Decreased TFR/TFH ratio in SIV-infected rhesus macaques may contribute to accumulation of TFH cells in chronic infection
2015-09-02 | E-GEOD-69756 | biostudies-arrayexpress
Transcriptomics A genetic circuitry linking Id-proteins (Id2 and Id3) and the AKT-FOXO-mTORC1 axis to suppress innate-variant TFH cell development, maintain T cell quiescence and prevent lymphomagenesis.
2015-03-04 | GSE64779 | GEO
Transcriptomics The Id-RAP1 axis is essential for glioma maintenance and residency of glioma cells in the perivascular niche
2013-04-30 | E-MTAB-1303 | biostudies-arrayexpress
Genomics Inflammation induced repression of Foxp3-bound chromatin in regulatory T cells [sequencing]
2014-04-12 | E-GEOD-55773 | biostudies-arrayexpress