Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kun Qu
PROVIDER: E-GEOD-57702 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Boxer Lisa D LD Barajas Brook B Tao Shiying S Zhang Jiajing J Khavari Paul A PA
Genes & development 20140901 18
ZNF750 controls epithelial homeostasis by inhibiting progenitor genes while inducing differentiation genes, a role underscored by pathogenic ZNF750 mutations in cancer and psoriasis. How ZNF750 accomplishes these dual gene regulatory impacts is unknown. Here, we characterized ZNF750 as a transcription factor that binds both the progenitor and differentiation genes that it controls at a CCNNAGGC DNA motif. ZNF750 interacts with the pluripotency transcription factor KLF4 and chromatin regulators R ...[more]