Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Antonio Gómez
PROVIDER: E-GEOD-57727 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cornella Helena H Alsinet Clara C Sayols Sergi S Zhang Zhongyang Z Hao Ke K Cabellos Laia L Hoshida Yujin Y Villanueva Augusto A Thung Swan S Ward Stephen C SC Rodriguez-Carunchio Leonardo L Vila-Casadesús Maria M Imbeaud Sandrine S Lachenmayer Anja A Quaglia Alberto A Nagorney David M DM Minguez Beatriz B Carrilho Flair F Roberts Lewis R LR Waxman Samuel S Mazzaferro Vincenzo V Schwartz Myron M Esteller Manel M Heaton Nigel D ND Zucman-Rossi Jessica J Llovet Josep M JM
Gastroenterology 20141231 4
<h4>Background & aims</h4>Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors.<h4>Methods</h4>By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymor ...[more]