Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Genomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile.


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Antonio Gómez 

PROVIDER: E-GEOD-57727 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background & aims</h4>Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer that develops in children and young adults without cirrhosis. Little is known about its pathogenesis, and it can be treated only with surgery. We performed an integrative genomic analysis of a large series of patients with FLC to identify associated genetic factors.<h4>Methods</h4>By using 78 clinically annotated FLC samples, we performed whole-transcriptome (n = 58), single-nucleotide polymor  ...[more]

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