Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Javier Irazoqui
PROVIDER: E-GEOD-57739 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
Visvikis Orane O Ihuegbu Nnamdi N Labed Sid A SA Luhachack Lyly G LG Alves Anna-Maria F AF Wollenberg Amanda C AC Stuart Lynda M LM Stormo Gary D GD Irazoqui Javier E JE
Immunity 20140529 6
Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation of the transcription factors involved. By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense. HLH-30 was activated shortly after Staphylococcus aureus infection, and drove the expression of close ...[more]
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