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MDA-9/Syntenin regulates differentiation and angiogenesis programs in Head and Neck Squamous Cell Carcinoma

ABSTRACT: We identified MDA-9/Syntenin (8q12) as a key component of HNSCC differentiation and angiogenesis. Robust reduction in the expression of cyclinD1, CDK4, CTNNB1, STAT3 and PI3K were evident in MDA- 9/Syntenein depleted cells, which was reversed following MDA-9/Syntenin overexpression in immortalized oral epithelial cells. To further elucidate the role of MDA-9/Syntenin in tumor growth and epithelial cell differentiation in vitro and in vivo by sielnicng its expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Catherine Dumur

PROVIDER: E-GEOD-57760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MDA-9/Syntenin regulates differentiation and angiogenesis programs in head and neck squamous cell carcinoma.

Oyesanya Regina A RA Bhatia Shilpa S Menezes Mitchell E ME Dumur Catherine I CI Singh Karan P KP Bae Sejong S Troyer Dean A DA Wells Robert B RB Sauter Edward R ER Sidransky David D Fisher Paul B PB Semmes Oliver J OJ Dasgupta Santanu S

Oncoscience 20140918 11

Little is known about the molecular pathways regulating poor differentiation and invasion of head and neck squamous cell carcinoma (HNSCC). In the present study, we aimed to determine the role of MDA-9/Syntenin, a metastasis associated molecule in HNSCC tumorigenesis. Elevated MDA-9/Syntenin expression was evident in 67% (54/81) primary HNSCC tumors (p=0.001-0.002) and 69% (9/13) pre-neoplastic tissues (p=0.02-0.03). MDA-9/Syntenin overexpression was associated with the stage (p=0.001), grade (p ...[more]

PMID: 25593999

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