Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Towards epigenetic understanding and therapy of insulin resistance by intranuclear insulin [mouse liver gene expression]


ABSTRACT: There is evidence indicating the involvement of DNA methylation memory in maintaining gene expression patterns associated with insulin resistance. Although the exact mechanism remains unknown, it has been proved that insulin resistance is correlated to low heat shock protein (HSP) expression. We reveal that intranuclear insulin can reduce HSP DNA methylation level to up-regulate HSP protein expression and result in long term cure of hyperglycemia. Type 2 diabetes KKAy mouse were selected in our experiments.Three conditions were compared with three replicates each. These are:(1) Untreated KKAy mouse (2) Insulin treated KKAy mouse(Insulin); (3) Biomineralized insulin treated KKAy mouse(BI).

ORGANISM(S): Mus musculus

SUBMITTER: Yun Xiao 

PROVIDER: E-GEOD-57817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2014-01-17 | E-GEOD-54134 | biostudies-arrayexpress
2010-04-22 | E-GEOD-19695 | biostudies-arrayexpress
2024-01-26 | PXD048915 | Pride
2018-05-04 | E-MTAB-6709 | biostudies-arrayexpress
2023-07-07 | E-MTAB-13152 | biostudies-arrayexpress
2012-03-23 | E-GEOD-36714 | biostudies-arrayexpress
2014-05-21 | GSE57817 | GEO
2014-05-23 | GSE57894 | GEO
2014-05-23 | GSE57893 | GEO
2014-05-23 | E-GEOD-57893 | biostudies-arrayexpress