Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

4TO7 cells: miR-23b/27b/24 overexpression vs control


ABSTRACT: Transcriptional profiling of 4TO7 cells featuring ectopic expression of miR-23b/27b/24 compared to vector control cells. Gene expression changes will be examined as potential direct targets of the miRNAs for use in later studies on metastasis suppression or activation. Two-condition experiment, miRNA overexpressing cells vs vector control. Biological replicates: 2 transfection replicates each.

ORGANISM(S): Mus musculus

SUBMITTER: Yong Wei 

PROVIDER: E-GEOD-57838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

The microRNA-23b/27b/24 cluster promotes breast cancer lung metastasis by targeting metastasis-suppressive gene prosaposin.

Ell Brian B   Qiu Qiong Q   Wei Yong Y   Mercatali Laura L   Ibrahim Toni T   Amadori Dino D   Kang Yibin Y  

The Journal of biological chemistry 20140625 32


MicroRNAs (miRNAs) have been shown to function as key regulators of tumor progression and metastasis. Recent studies have indicated that the miRNAs comprising the miR-23b/27b/24 cluster might influence tumor metastasis, although the precise nature of this regulation remains unclear. Here, expression of the miR-23b/27b/24 cluster is found to correlate with metastatic potential in mouse and human breast cancer cell lines and is elevated in metastatic lung lesions in human breast cancer patients. E  ...[more]

Similar Datasets

2014-12-23 | GSE57838 | GEO
2016-02-10 | GSE76620 | GEO
2016-02-10 | E-GEOD-76620 | biostudies-arrayexpress
2017-08-12 | GSE86069 | GEO
| PRJNA248212 | ENA
2015-06-18 | E-GEOD-67631 | biostudies-arrayexpress
2013-05-01 | E-GEOD-37918 | biostudies-arrayexpress
2014-01-07 | E-GEOD-53872 | biostudies-arrayexpress
2015-06-18 | GSE67631 | GEO
2015-09-22 | E-GEOD-73275 | biostudies-arrayexpress