Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rossana Maffei
PROVIDER: E-GEOD-57861 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Haematologica 20141114 2
Lenalidomide is an immunomodulatory agent clinically active in chronic lymphocytic leukemia patients. The specific mechanism of action is still undefined, but includes modulation of the microenvironment. In chronic lymphocytic leukemia patients, nurse-like cells differentiate from CD14(+) mononuclear cells and protect chronic lymphocytic leukemia cells from apoptosis. Nurse-like cells resemble M2 macrophages with potent immunosuppressive functions. Here, we examined the effect of lenalidomide on ...[more]