Transcriptome profiling in human T-ALL
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Thomas Trimarchi
PROVIDER: E-GEOD-57982 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia.
Trimarchi Thomas T Bilal Erhan E Ntziachristos Panagiotis P Fabbri Giulia G Dalla-Favera Riccardo R Tsirigos Aristotelis A Aifantis Iannis I
Cell 20140701 3
Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemia (T-ALL). By integrating transcriptome profiles with chromatin state maps, we have uncovered many previously unreported T-ALL-specific lncRNA genes, a fraction of which are directl ...[more]
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