Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Rosalie Sears
PROVIDER: E-GEOD-58008 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Janghorban Mahnaz M Farrell Amy S AS Allen-Petersen Brittany L BL Pelz Carl C Daniel Colin J CJ Oddo Jessica J Langer Ellen M EM Christensen Dale J DJ Sears Rosalie C RC
Proceedings of the National Academy of Sciences of the United States of America 20140609 25
The transcription factor c-MYC is stabilized and activated by phosphorylation at serine 62 (S62) in breast cancer. Protein phosphatase 2A (PP2A) is a critical negative regulator of c-MYC through its ability to dephosphorylate S62. By inactivating c-MYC and other key signaling pathways, PP2A plays an important tumor suppressor function. Two endogenous inhibitors of PP2A, I2PP2A, Inhibitor-2 of PP2A (SET oncoprotein) and cancerous inhibitor of PP2A (CIP2A), inactivate PP2A and are overexpressed in ...[more]