Transcriptional profiling of E. coli cultures exposed to tellurite 0.5 µg/ml
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli K-12
SUBMITTER: David Loyola
PROVIDER: E-GEOD-58176 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Global transcriptomic analysis uncovers a switch to anaerobic metabolism in tellurite-exposed Escherichia coli.
Molina-Quiroz Roberto C RC Loyola David E DE Díaz-Vásquez Waldo A WA Arenas Felipe A FA Urzúa Ulises U Pérez-Donoso José M JM Vásquez Claudio C CC
Research in microbiology 20140715 7
Tellurite (TeO3(2-)) is harmful for most microorganisms, especially Gram-negative bacteria. Even though tellurite toxicity involves a number of individual aspects, including oxidative stress, malfunctioning of metabolic enzymes and a drop in the reduced thiol pool, among others, the general mechanism of toxicity is rather complex and not completely understood to date. This work focused on DNA microarray analysis to evaluate the Escherichia coli global transcriptomic response when exposed to the ...[more]
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