Integrated epigenetic and copy-number profiling identifies three clinically and biologically relevant groups of anaplastic glioma

ABSTRACT: The outcome of patients with anaplastic gliomas varies considerably depending on histology and single molecular markers such as codeletion of 1p/19q and mutations of the isocitrate dehydrogenase (IDH) gene. Whether a molecularly-based classification of anaplastic gliomas based on large scale genomic or epigenomic analyses is superior to histopathology, may reflect distinct biological subtypes, predict outcome and guide therapy decisions had yet to be determined. Epigenome-wide DNA methylation analysis, which also allows for the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas and oligodendrogliomas), including 115 patients of the NOA-04 trial. We further compared these tumors with a group of 55 glioblas

ORGANISM(S): Homo sapiens

SUBMITTER: Martin Sill 

PROVIDER: E-GEOD-58218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress