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Transcription profiling of whole mammary glands from female mice at different developmental stages to identify transcripts that are differentially expressed in the mammary gland in wild type C57BL/6J mice.

ABSTRACT: This study was performed to identify transcripts that are differentially expressed in the mammary gland at 4 stages of developmental (virgin, pregnant, lactating and involution) in wild type C57BL/6J mice. Experiment Overall Design: Whole mammary glands No4 (inguinal) were obtained from female mice at 4 stages of development: Virgin (puberty, 6 wks of age), Pregnant (14 days of pregnancy), Lactating (day 10 postpartum) and Involution (4 days post weaning of pups). Three biological replicates were obtained from Virgin females and two biological replicates for the three other stages. mice

ORGANISM(S): Mus musculus

SUBMITTER: Juan Medrano

PROVIDER: E-GEOD-5831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Combining mouse mammary gland gene expression and comparative mapping for the identification of candidate genes for QTL of milk production traits in cattle.

Ron Micha M Israeli Galit G Seroussi Eyal E Weller Joel I JI Gregg Jeffrey P JP Shani Moshe M Medrano Juan F JF

BMC genomics 20070620

<h4>Background</h4>Many studies have found segregating quantitative trait loci (QTL) for milk production traits in different dairy cattle populations. However, even for relatively large effects with a saturated marker map the confidence interval for QTL location by linkage analysis spans tens of map units, or hundreds of genes. Combining mapping and arraying has been suggested as an approach to identify candidate genes. Thus, gene expression analysis in the mammary gland of genes positioned in t ...[more]

PMID: 17584498

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