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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human transplanted intestine before signs of rejects and when there was signs of actue cellular rejection

ABSTRACT: Acute cellular rejection (ACR) is the major cause of intestinal graft loss. Little is known about the genetic response occurring in small bowel transplantation (SBTx) during ACR. We report the case of a 44 year-old female with short gut syndrome following multiple surgeries for familial adenomatous polyposis that underwent living-related SBTx. We obtained for the first time a gene expression profile of the intestinal graft during ACR. Microarray analysis revealed increased transcript levels for genes that match identically to an IFN? signature reported for activated plasmacytoid dendritic cells and T-cell chemotaxis and cytolysis correlating with the diagnosis of ACR. Experiment Overall Design: sam1, sam2, sam3 (without signs of rejection) Experiment Overall Design: sam4, sam5, sam6 (with signs and symptoms of rejection , histology showed increasing lymphocyte infiltration in the lamina propria and epithelium)

ORGANISM(S): Homo sapiens

SUBMITTER: Georg Elias

PROVIDER: E-GEOD-5838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from transplanted intestine bifor signs of rejection, and when their was signs of rejection

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