Transcription profiling of rat brain to identify candidate genes for alcohol preference in congenic strains

ABSTRACT: A highly significant quantitative trait locus (QTL) that influenced alcohol preference was identified in the iP/iNP rats on chromosome 4. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol; consumption compared to the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might; contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains. RNA from five brain regions; from each of 6 NP.P and 6 iNP rats was labeled and analyzed separately on an Affymetrix Rat Genome 230 2.0 microarray. Expression levels; were normalized using robust multi-chip average (RMA). Differential gene expression was validated using q

ORGANISM(S): Rattus norvegicus

SUBMITTER: Mark William Kimpel 

PROVIDER: E-GEOD-5849 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress