Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shirin Khambata Ford
PROVIDER: E-GEOD-5851 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Khambata-Ford Shirin S Garrett Christopher R CR Meropol Neal J NJ Basik Mark M Harbison Christopher T CT Wu Shujian S Wong Tai W TW Huang Xin X Takimoto Chris H CH Godwin Andrew K AK Tan Benjamin R BR Krishnamurthi Smitha S SS Burris Howard A HA Poplin Elizabeth A EA Hidalgo Manuel M Baselga Jose J Clark Edwin A EA Mauro David J DJ
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070801 22
<h4>Purpose</h4>The antiepidermal growth factor receptor (EGFR) antibody cetuximab shows activity in multiple epithelial tumor types; however, responses are seen in only a subset of patients. This study was conducted to identify markers that are associated with disease control in patients treated with cetuximab.<h4>Patients and methods</h4>One hundred ten patients with metastatic colorectal cancer were enrolled onto a cetuximab monotherapy trial. Transcriptional profiling was conducted on RNA fr ...[more]