Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human patients with advances metastatic colo-rectal cancer - phase II exploratory pharmacogenomics study of cetuximab monotherapy


ABSTRACT: Patients with metastatic colorectal cancer were enrolled for treatment with cetuximab monotherapy. Transcriptional profiling was conducted on RNA from pre-treatment metastatic site biopsies to identify genes whose expression correlates with best clinical responses. Experiment Overall Design: single pre-treatment metastatic biopsy from each patient analyzed

ORGANISM(S): Homo sapiens

SUBMITTER: Shirin Khambata Ford 

PROVIDER: E-GEOD-5851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.

Khambata-Ford Shirin S   Garrett Christopher R CR   Meropol Neal J NJ   Basik Mark M   Harbison Christopher T CT   Wu Shujian S   Wong Tai W TW   Huang Xin X   Takimoto Chris H CH   Godwin Andrew K AK   Tan Benjamin R BR   Krishnamurthi Smitha S SS   Burris Howard A HA   Poplin Elizabeth A EA   Hidalgo Manuel M   Baselga Jose J   Clark Edwin A EA   Mauro David J DJ  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070801 22


<h4>Purpose</h4>The antiepidermal growth factor receptor (EGFR) antibody cetuximab shows activity in multiple epithelial tumor types; however, responses are seen in only a subset of patients. This study was conducted to identify markers that are associated with disease control in patients treated with cetuximab.<h4>Patients and methods</h4>One hundred ten patients with metastatic colorectal cancer were enrolled onto a cetuximab monotherapy trial. Transcriptional profiling was conducted on RNA fr  ...[more]

Similar Datasets

2008-01-31 | GSE5851 | GEO
2016-07-17 | GSE71210 | GEO
2016-07-17 | E-GEOD-71210 | biostudies-arrayexpress
2017-03-02 | GSE63916 | GEO
| PRJNA435545 | ENA
2012-07-13 | E-GEOD-23428 | biostudies-arrayexpress
2020-01-17 | GSE109756 | GEO
2020-05-06 | GSE108277 | GEO
2012-07-14 | GSE23428 | GEO
2020-11-02 | GSE141352 | GEO