Unknown,Transcriptomics,Genomics,Proteomics

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Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster


ABSTRACT: We used RNA-seq to investigate gene expression variation in Malpighian tubules, which have a function analogous to that of human kidneys. In order to characterize population differentiation, we sequenced the Malpighian tubule transcriptomes of flies derived from two populations, one from sub-Saharan Africa (Zimbabwe) and one from Europe (the Netherlands). Males and females were examined separately. Overall, we found a high amount of differential expression between sexes (2,308 genes) and populations (2,474 genes). Although most of the differentially expressed genes were consistent between sexes and populations, there were 615 genes showed sex-biased expression in only one population and 557 genes showed population-biased expression in only one sex. mRNA expression profiles of Drosophila melanogaster Malpighian tubules from adult males and females from a European and an African population (2 biological replicates per sex and population)

ORGANISM(S): Drosophila melanogaster

SUBMITTER: John Parsch 

PROVIDER: E-GEOD-58578 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster.

Huylmans Ann Kathrin AK   Parsch John J  

G3 (Bethesda, Md.) 20140922 12


Within species, levels of gene expression typically vary greatly between tissues, sexes, individuals, and populations. To investigate gene expression variation between sexes and populations in a single somatic tissue, we performed a quantitative analysis of the Malpighian tubule transcriptome in adult males and females of Drosophila melanogaster derived from two distinct populations (one from sub-Saharan Africa and one from northern Europe). We identified 2308 genes that differed in expression b  ...[more]

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