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Transcription profiling of human lymphoblasts from HapMap populations CEU, CHB, JPY reveals allelic differences account for gene expression differences among populations

ABSTRACT: Expression level of genes in lymphoblasts from individuals in three HapMap populations (CEU, CHB, JPT) were compared. More than 1,000 genes were found to be significantly different (Pc<0.05) in mean expression level between the CEU and CHB+JPT samples. Experiment Overall Design: Gene expression analysis using Affymetrix Human Focus arrays; comparison of expression levels of genes by t-test.

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Morley

PROVIDER: E-GEOD-5859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Common genetic variants account for differences in gene expression among ethnic groups.

Spielman Richard S RS Bastone Laurel A LA Burdick Joshua T JT Morley Michael M Ewens Warren J WJ Cheung Vivian G VG

Nature genetics 20070107 2

Variation in DNA sequence contributes to individual differences in quantitative traits, but in humans the specific sequence variants are known for very few traits. We characterized variation in gene expression in cells from individuals belonging to three major population groups. This quantitative phenotype differs significantly between European-derived and Asian-derived populations for 1,097 of 4,197 genes tested. For the phenotypes with the strongest evidence of cis determinants, most of the va ...[more]

PMID: 17206142

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Allelic Differences Account for Gene Expression Differences Among Population.

Project description:Expression level of genes in lymphoblasts from individuals in three HapMap populations (CEU, CHB, JPT) were compared. More than 1,000 genes were found to be significantly different (Pc<0.05) in mean expression level between the CEU and CHB+JPT samples. Keywords: Comparison of Gene Expression Profiles from Lymphoblastoid cells

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